Supplements are used even in ecologic nutrition. Without them food industry could not exist. Thank to them we can obtain products with lower proportion of sugar, fat and caloric energy. We know that the food we buy is good for consumption; without them, it could spoil, change its appearance, be a threat to life (botulinum toxin).
However there are products where additional materials is not used. For instance honey, water, milk, vegetables, fruits, raw meat and fish.